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与慢性病相关的死亡风险在患有完整左捆分支块的患者中
Hui-Chun Huang1,2, Chun-Kai Chen3, Yen-Bin Liu1
1Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Scientific reports
|August 2, 2024
概括
慢性病 (CKD) 显著增加了患者的死亡风险 完整的左捆分支阻塞 (cLBBB). 在这些患者中,早期发现和治疗CKD对于改善结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是心力衰竭和心脏导电异常的已知危险因素.
- 完整的左捆分支阻塞 (cLBBB) 可以使心室同步恶化,并导致心力衰竭的进展.
- 在CKD和心力衰竭之间存在协同的负面影响,创造了一个有害的循环.
研究的目的:
- 调查慢性病对诊断为cLBBB的患者死亡率的影响.
- 评估估计的膜过率 (eGFR) 在预测这个患者群体的结果中的作用.
主要方法:
- 一组416名患有cLBBB的成年患者的医院队列被追溯分析 (2010-2013).
- 使用CKD-EPI方程计算估计的淋巴球过率 (eGFR).
- 考克斯的比例危险模型被用来确定所有原因和心血管死亡率的预测因素.
主要成果:
- 晚期CKD (eGFR<60 mL/min/1.73 m2) 是cLBBB患者总死亡率的重要独立预测因子.
- 与没有CKD的患者相比,cLBBB患者中CKD的存在大大增加了总死亡率 (HR 5.01) 和心血管死亡 (HR 61.78) 的风险.
- 年龄较大,充血性心力衰竭,心率较高和缺乏ACEI/ARB使用也预测了较高的总死亡率.
结论:
- 慢性脏病是cLBBB.患者全因死亡率增加的关键风险因素.
- 这些发现强调了在治疗cLBBB患者时考虑功能的重要性,以减轻死亡风险.
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