一项回顾性研究检查了多药与腹腔镜手术后结直肠癌并发症之间的关联
Takashi Watanabe1,2, Shota Kashiwagura3, Ryusuke Ouchi4,3
1Division of Clinical Pharmaceutics and Pharmacy Practice, Tohoku Medical and Pharmaceutical University, 1-15-1, Fukumuro, Miyagino-ku, Sendai, 983-8536, Japan. watanabe.taka@tohoku-mpu.ac.jp.
Journal of pharmaceutical health care and sciences
|August 2, 2024
概括
多药性,即使用多种药物,与经过腹腔镜手术的结直肠癌患者的术后并发症增加有关. 使用十个或更多的药物成分显著增加并发症风险.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 多药是全球日益严重的健康问题.
- 对于结直肠癌而言,腹腔外科手术是常见的.
- 了解多药对手术结果的影响至关重要.
研究的目的:
- 为了调查腹腔镜结肠直肠癌手术后的术后并发症.
- 探索多药与这些并发症之间的关联.
主要方法:
- 对236名接受了腹腔镜结肠直肠癌手术的患者进行了回顾性图表审查.
- 使用Clavien-Dindo分类来评估并发症.
- 多变量后勤回归确定了多药的风险因素和切线值.
主要成果:
- 13.6%的患者经历了术后并发症.
- 定期使用的药物成分的数量是一个显著的预测指标 (OR 1.160,p=0.002).
- 切断10种成分表明并发症率高3.5倍 (33.3%对9.3%).
结论:
- 多药学,特别是使用10个以上的药物成分,与腹腔镜结直肠癌手术中术后并发症的增加有关.
- 这些发现强调了在术后管理中需要仔细审查药物治疗的必要性.
- 这项研究提供了改善患者护理和结果的见解.
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