高风险的人类乳头瘤病毒感染和宫细胞病理学:与宫氧化水平的关系

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Doaa Mahdy El-Wakil¹, Olfat G Shaker², Ahmed S S A Rashwan³

¹Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Al-Saray Street, Al-Manial, Cairo, 11562, Egypt. do3aamahdy@cu.edu.eg.

Virology journal

|August 2, 2024

概括

宫氧化代谢物 (NOx) 水平升高与高风险的人类乳头瘤病毒 (hrHPV) 感染和宫癌前变化有关. 这些发现表明,NOx可以作为预测 hrHPV 感染和表皮性异型的生物标志物.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
生物化学生物化学

背景情况:

高风险的人类乳头瘤病毒 (hrHPV) 感染是导致宫癌的主要原因.
氧化 (NO) 可能在 hrHPV 感染的持续性方面发挥作用.
子宫癌的发展与先发性病变有关.

研究的目的:

调查宫氧化代谢物 (NOx) 水平与 hrHPV 感染之间的关联.
评估宫NOx水平与细胞病理学发现之间的相关性,包括表皮性异常.
评估宫NOx作为预测HRHPV感染和上皮异常的生物标志物的潜力.

主要方法:

这项研究包括了74名参加妇科门诊的妇女.
宫样本经过了Pap检测,使用格里斯方法评估NOx水平,并通过实时PCR检测hrHPVDNA.
数据是在2021年11月至2022年8月期间收集的.

主要成果:

在37.8%的参与者中检测到高风险HPV,其中HPV 16是最常见的基因型 (89.3%).
宫NOx水平在hHPV阳性病例中 (37.4μmol/mL) 与hHPV阴性病例 (2.3μmol/mL) 相比显著更高.
较高的NOx水平与高度的缺陷相关,并且显示出对预测 hrHPV 感染 (>23.61 μmol/mL) 和上皮缺陷 (>11.35 μmol/mL) 的诊断准确性.

结论:

观察到高频率的HRHPV感染,特别是HPV 16,需要有针对性的查和治疗.
宫NOx水平升高与 hrHPV感染和高度宫异常症有显著的相关性.
宫NOx可以作为一种有价值的生物标志物,用于早期检测hHPV感染和异常细胞学变化.

关键词:

亚型性亚型性亚型性宫氧化的使用方法细胞病理学细胞病理学基因型基因型基因型高风险的人类乳头瘤病毒 (hrHPV)

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