我们如何管理与药物相关的骨骨
H Byrne1, S O'Reilly2,3, C S Weadick2,3
1Cork University Dental School and Hospital, University College Cork, Cork, Ireland. Harriet.byrne@ucc.ie.
European journal of medical research
|August 2, 2024
概括
骨修饰剂可以提高癌症生存率,但可以导致与药物相关的骨缩症 (MRONJ). 本综述详细介绍了MRONJ针对癌症患者的预防和管理策略,这些重要疗法.
科学领域:
- 在瘤学瘤学.
- 牙科医学 牙科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨修饰剂 (BMA) 对于治疗晚期癌症至关重要,通过减少骨事件和骨损失来改善生存率.
- 与药物相关的下巴骨髓缩症 (MRONJ) 在20年前作为BMA治疗的并发症出现,风险持续超过10年.
- 此外,MRONJ还与其他癌症治疗相关,如抗血管性,细胞毒性,免疫疗法和向性药物,从而增加了其临床意义.
研究的目的:
- 审查在接受BMA治疗的癌症患者中对MRONJ的预防和管理策略的演变.
- 为了突出MRONJ的日益严重的影响,由于BMA在治疗和辅助癌症环境中的使用增加.
- 倡导将牙科瘤学纳入癌症护理,以提高长期生存质量.
主要方法:
- 在过去20年中,对MRONJ的主要风险因素,病理生理学和管理策略的文献综述.
- 分析MRONJ预防和管理方法的发展.
- 关于BMA和其他癌症治疗对MRONJ的影响的综合证据.
主要成果:
- 在二十年内巩固了MRONJ的主要风险因素,病理生理学和管理策略.
- 鉴定MRONJ作为与双酸盐治疗相关的持续风险,使牙科手术复杂化.
- 在BMA以外的各种癌症治疗方式中识别MRONJ风险.
结论:
- 牙科瘤学策略应纳入当代癌症护理,以优化患者的治疗结果.
- 有效管理和预防MRONJ对于改善癌症患者的生存质量至关重要.
- 为了应对MRONJ在瘤实践中所带来的挑战,需要持续的研究和临床警.
相关概念视频
01:26Peptic Ulcer Disease IV: Management
79
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
79
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
264
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
264
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:40Bone Remodeling
38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.2K
01:13Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
363
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
363