基托桑分子量对素载荷基托桑纳米粒子的基托桑分子量的影响
Feng Geng1, Mengyang Zhang1, Tao Sun1
1College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Journal of the science of food and agriculture
|August 3, 2024
概括
基托桑分子量影响奎尔塞丁纳米颗粒的特性. 较高的分子重量奇多导致较小的素载奇多纳米颗粒,具有增强的稳定性和抗氧化活性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物化学 生化学
背景情况:
- 奎尔丁的治疗潜力受到溶解性差,不稳定性和口服生物可用性低的阻碍.
- 纳米颗粒封装提供了一个有前途的策略,以提高氨酸的输送和有效性.
研究的目的:
- 为了研究基托分子量 (Mw) 对素载荷基托纳米颗粒 (QCNPs) 特性的影响.
- 评估Mw的变化如何影响QCNP结构,稳定性,释放动力学和抗氧化性质.
主要方法:
- 奎尔赛丁被装入具有不同分子量 (100, 200, 500, 1000 kDa) 的奇托桑纳米颗粒中.
- 描述包括评估颗粒大小,多分散性指数,稳定性 (光稳定性,热稳定性),释放概况和抗氧化活性.
- 采用X射线衍射来确认奎尔塞丁封装.
主要成果:
- 增加基托Mw导致QCNP颗粒大小减少和多分散性增加.
- 鉴定出结合和疏水相互作用是QCNP形成的关键力量.
- 更高的Mw显著改善了QCNP的光稳定性和热稳定性.
- 具有最高Mw的QCNP (QCNP-100) 表明药物释放率最低.
- QCNPs的抗氧化活性增加了基托桑Mw,其中QCNP-100显示了最高的活性.
结论:
- 基托的分子重量是影响素载基托纳米粒子特性的一个关键因素.
- QCNP-100,来自最高Mw奇托,表现出最佳的特征:最小的颗粒大小,优越的稳定性,可控释放,和强大的抗氧化活性.
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