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超重与COVID-19结果之间的关联:一个综合性审查
Jamie Matu1, Alex Griffiths1, Oliver M Shannon2
1Obesity Institute, School of Health, Leeds Beckett University, Leeds, UK.
超重的个体在COVID-19感染后面临严重后果,包括死亡的风险明显更高. 这一综合性综述强调肥胖是COVID-19不良结果的关键,可修改的风险因素.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 超重是一个日益严重的全球健康问题.
- 肥胖和COVID-19严重程度之间的关联需要全面评估.
研究的目的:
- 对超重与COVID-19结果之间的关联进行总体审查和二级元分析.
- 综合关于重症监护室入院,侵入性机械通风,疾病严重程度,住院和超重个体死亡率的证据.
主要方法:
- 在MEDLINE,PsycINFO和CINAHL系统搜索相关的系统审查.
- 包括52个系统性审查,其中49个具有元分析.
- 使用AMSTAR-2工具对包含的审查进行质量评估.
主要成果:
- 超重个体的严重结局 (OR=1.86),ICU入院 (OR=1.58),机械呼吸 (OR=1.70),住院 (OR=1.82),以及COVID-19死亡率 (OR=1.35) 的风险显著更高.
- 只有有限的证据证明了像种族这样的缓和因素.
- 大多数包含的评论质量不佳.
结论:
- 超重是严重的COVID-19结果和死亡率的显著可修改的风险因素.
- 公共卫生战略应解决肥胖问题,以减轻COVID-19的影响.
- 需要进一步进行高质量的研究,以探索缓解因素.
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