精子DNA碎片化对无法解释的重复妊娠流产的夫妇的影响:一个横截面研究
Megha Solanki1, Treasa Joseph2, K Muthukumar2
1Department of Reproductive Medicine and Surgery, Christian Medical College, Vellore, India.
The journal of obstetrics and gynaecology research
|August 3, 2024
概括
精子DNA碎片化 (SDF) 可能导致不明原因的重复妊娠损失 (RPL). 虽然平均SDF水平相似,但患有不明原因的RPL的男性显示出更高比例的显著DNA碎片化 (≥30%).
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 遗传学 遗传学 是一个
背景情况:
- 复发性流产 (RPL) 通常具有无法解释的病因.
- 传统的精液分析可能无法充分评估男性生育因素.
- 精子DNA碎片化 (SDF) 是男性生殖健康的新兴标志物.
研究的目的:
- 调查精子DNA碎片化 (SDF) 对经历不明原因重复妊娠损失 (RPL) 的夫妇的影响.
- 评估SDF是否可以解释部分无法解释的RPL病例.
主要方法:
- 一项分析横截面研究涉及70名男性:35名男性伴侣的夫妇有不明原因的RPL和35名对照.
- 评估了精液参数,包括精子DNA碎片化指数 (DFI),度,运动性和形态.
- 参与者没有接受辅助生殖技术 (ART).
主要成果:
- 平均DNA碎片化指数 (DFI) 在不明原因的RPL病例和对照人群之间没有显著差异.
- 与对照组相比,有显著更高比例的男性患有不明原因的RPL患有高DFI (≥30%) (54.2%对25.7%).
- SDF显示与精子形态学有着显著的反向关系.
结论:
- 这项研究没有发现RPL和对照对象之间的平均SDF水平有显著差异.
- 然而,在无法解释的RPL组中观察到较高SDF (≥30%) 的更高流行率.
- SDF,特别是高碎片化,可能在不明原因的RPL中发挥作用.
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