发展中的小鼠呼吸系统的组织学地图,从产前9.0天到产后30天
Vanessa R Parslow1, Susan A Elmore2, Robert Z Cochran3
1Inotiv-RTP, Morrisville, North Carolina, USA.
Toxicologic pathology
|August 3, 2024
概括
这本地图集提供了小鼠呼吸系统发育的详细图像. 它有助于研究人员识别正常解剖与呼吸系统疾病的小鼠模型中的疾病相关异常.
科学领域:
- 发展生物学 发展生物学
- 比较病理学比较病理学
- 人体解剖学 解剖学 解剖学
背景情况:
- 呼吸道疾病是全球主要的健康负担.
- 小鼠是研究人类呼吸道疾病的关键模型.
- 现有的文献缺乏对正常的小鼠呼吸系统发育进行全面的视觉参考.
研究的目的:
- 为了创建一个详细的老鼠呼吸系统发展的地图.
- 提供H&E染色部分的高分辨率图像.
- 帮助区分正常发育与研究模型中的异常.
主要方法:
- 编译了H&E染色小鼠呼吸道组织的全幻灯片扫描.
- 关键解剖结构的详细注释.
- 专注于胚胎日 (E) 9.0至18.5和出生后早期阶段.
主要成果:
- 建立了一份关于小鼠呼吸道正常发育的综合图谱.
- 高分辨率图像说明了关键结构和发展事件.
- 这本地图书涵盖了上呼吸道和下呼吸道.
结论:
- 这本地图是研究人员使用小鼠模型的重要参考资料.
- 它通过定义正常形态来促进准确的表型分析.
- 该资源有助于识别先天性和与治疗有关的异常.
相关概念视频
Anatomy of Respiratory System I: Upper Respiratory Tract
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
Anatomy of Respiratory System II: Lower Respiratory Tract
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...


