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在瘤学中下一代测序:经济评估中的挑战

Morgan Ehman¹, Jesman Punian¹, Deirdre Weymann^1,2

¹Cancer Control Research, BC Cancer, Vancouver, BC, Canada.

Expert review of pharmacoeconomics & outcomes research

|August 3, 2024

概括

癌症护理中的下一代测序 (NGS) 面临着成本效益方面的挑战. 解决这些问题需要调整方法并使用现实世界的证据 (RWE) 来实现更好的医疗保健整合.

科学领域:

在瘤学瘤学.
卫生经济学卫生经济学
基因组学就是基因组学.

背景情况:

下一代测序 (NGS) 通过识别遗传变异来提供个性化癌症治疗.
然而,由于成本效益的证据不足,阻碍了其在癌症护理中的常规整合.
个性化医学的复杂性使传统的经济评估变得更加复杂.

研究的目的:

审查瘤学中NGS的经济评估方法.
确定在评估NGS导向癌症治疗的成本效益方面的挑战.
为未来的经济分析提供信息,以便更好地评估结果.

主要方法:

这是一个对自2016年以来发表的27篇文章的范围审查.
在PubMed,Embase和Web of Science进行的搜索.
对NGS经济评估中应用的方法和结果的分析.

主要成果:

确定的主要挑战包括定义评估范围和管理证据限制.
报告指出,在纳入基于优惠的公用事业和评估股权影响方面存在困难.
这些挑战源于高质量的临床有效性和现实世界的证据 (RWE) 对NGS干预措施的稀缺性.

结论:

适应方法方法和利用RWE进行健康技术评估 (HTA) 是NGS在瘤学中的实施至关重要的.
需要创新的监管和报销流程来支持可持续,公平和以患者为中心的癌症护理.

关键词:

经济评估经济评价卫生技术评估卫生技术评估这是下一代测序.精确瘤学精确瘤学现实世界的证据.

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