在儿童癌症患者和幸存者中输血性血
Jacquelyn Baskin-Miller1, Susan Carson2, Julie Jaffray3
1Division of Pediatric Hematology Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Pediatric blood & cancer
|August 3, 2024
概括
接受输血的儿童癌症患者往往会出现铁过载,影响肝脏和胰腺等器官. 这项研究强调了这些儿童广泛的肝外铁负荷,强调了需要进一步研究的必要性.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 放射学 放射学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 接受癌症治疗的儿童面临铁过载的风险,这是由于在骨髓抑制期间的输血造成的.
- 这可能导致有毒铁暴露,肝外铁积累和长期器官损伤.
研究的目的:
- 在儿童癌症患者中描述临床显著的多系统铁过载 (IO) 的严重程度和器官分布.
- 为了确定铁的分布和临床特征之间的关联.
主要方法:
- 对103名儿科癌症患者进行了回顾性,横截面研究,临床关注IO.
- 磁共振成像 (MRI) 用于评估铁过载.
- 分析了癌症治疗,输血史,MRI发现和实验室结果的数据.
主要成果:
- 超过80%的患者表现出肝外铁负荷,其中53%显示中度或较大的肝硬化症和80%的胰腺硬化症.
- 在45%的评估患者中观察到下垂体 siderosis.
- 胰腺铁与心脏和垂体铁有显著的相关性,治疗和治疗之外的患者之间的费里水平有所不同.
结论:
- 严重治疗的儿科癌症患者经常经历显著的肝外铁负荷.
- 这与输血中的铁暴露和大脑髓活动的降低有关.
- 需要进一步的研究,以了解反应性铁暴露的长期影响,并制定管理策略.
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