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Updated: Jun 18, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

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蛋白质药物与智能EnteroPatho纳米颗粒的平细胞传递

Isabela Ramirez-Velez1, Aditya A Namjoshi1, Unyime M Effiong1

  • 1McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.

ACS nano
|August 3, 2024
PubMed
概括

研究人员开发出智能纳米粒子,可以暂时在肠道中打开通道. 这一突破使得蛋白质药物的有效口服输送成为可能,改善了患者的获取并降低了医疗保健成本.

关键词:
双释放式的双释放方式葡萄糖糖的性糖质 (glycocalyx) 是一种纳米颗粒是一种纳米粒子.在口服交付口服交付.类似细胞的通透性.紧密的交叉路口紧密的连接

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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