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在热带适应的印度杂交牛中,对HSP90AA1多态与热耐受性的关联分析

Rakesh Kumar¹, Ragini Kumari², Archana Verma³

¹ICAR-Research Complex for Eastern Region, Patna, Bihar, 800014, India. rakesh05vet@gmail.com.

Tropical animal health and production

|August 3, 2024

概括

在Karan Fries牛群中发现了HSP90AA1基因的遗传变异,其中一个特定的SNP与改善的耐热性和牛奶产量有显著联系. 这些发现提供了有价值的标记,用于提高牛养殖计划中的耐热性.

科学领域:

动物遗传学和动物繁殖
畜牧业生产畜牧业生产
农业中的气候变化适应农业中的气候变化适应

背景情况:

全球畜牧业因热压力而面临经济损失.
热冲击蛋白 (HSP),特别是HSP90,在保护细胞免受热的过程中起着至关重要的作用.
HSP90AA1基因的适应性与牛在热应激下生理弹性有关.

研究的目的:

在Karan Fries牛中识别HSP90AA1基因中的遗传多态性.
调查这些多态和与热耐受性和生产相关的特征之间的关联.

主要方法:

针对HSP90AA1基因多态的100头Karan Fries牛的基因定型.
在Intron 8和Exon 11中识别单核酸多态 (SNPs).
对SNP和单元类型的关联分析与呼吸速率,耐热系数和总牛奶产量.
使用Haploview 4.2和SHEsis软件进行链接不平衡和哈普类型分析.

主要成果:

在Intron 8中,一个SNP (g.3292 A>C) 与呼吸速率,耐热系数和总牛奶产量显著相关 (P<0.01).
在其他已识别的SNP (g.4776 A>G,g.5218T>C,g.5224 A>C) 与研究的特征之间没有发现显著的相关性.
鉴定出Hap3 (CATA) 类型对Karan Fries牛的耐热繁殖有益.

结论:

在HSP90AA1基因中的遗传多态和单元类型与牛的热耐力有关.
鉴定到的SNP和单元型可以作为遗传选择的有价值的分子标记.
这项研究为标记器辅助的选择提供了基础,以提高牛养殖平台的耐热性.

关键词:

牛群是牛群,牛群就是牛群.HSP90AA1AA1 的时间哈普洛型是指一种类型.多态性多态性多态性热应力是一种热应力.

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