使用皮下瘤模型建立小鼠自发转移的协议
Shiqin Liu1, Michelle Shen1, Kewei Le1
1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
STAR protocols
|August 3, 2024
概括
这项研究详细介绍了一种用于自发癌症转移的小鼠模型协议. 它使研究人员能够研究癌症的进展,并在体内测试新的治疗方法.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床前模型 临床前模型
背景情况:
- 自发转移复制对于癌症研究至关重要.
- 了解癌症进展和治疗干预措施需要准确的临床前模型.
研究的目的:
- 介绍一项用于建立和表征小鼠自发转移模型的协议.
- 为研究体内转移和评估治疗策略提供一种工具.
主要方法:
- 产生主要瘤.
- 进行瘤切除.
- 监测转移性传播.
- 使用组织学和成像技术评估转移性负担.
主要成果:
- 该协议允许在小鼠中建立和表征自发转移.
- 它有助于在临床前环境中研究癌症进展和转移.
结论:
- 该协议是癌症转移研究的宝贵工具.
- 它有助于测试预防或向转移性疾病的治疗策略.
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