在T1桃体状细胞癌患者中,淋巴结转移的风险根据诊断时的年龄分层
1Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai 201321, China; Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai 201321, China; Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Shanghai, China.
American journal of otolaryngology
|August 3, 2024
概括
年轻的桃体状细胞癌 (TSCC) 患者患有淋巴结转移 (LNM) 的风险更高. 高龄与较低的LNM风险有关,除亚洲患者外,建议量身定制的治疗方法.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
- 癌症流行病学 癌症流行病学
背景情况:
- 桃体状细胞癌 (TSCC) 是一种严重的头恶性瘤.
- 淋巴结转移 (LNM) 是TSCC的关键预后因素.
- 早期TSCC患者的患者年龄和LNM风险之间的关系需要进一步阐明.
研究的目的:
- 调查患者年龄与T1桃体状细胞癌 (TSCC) 中淋巴结转移 (LNM) 的存在之间的关联.
- 在早期TSCC中确定影响LNM的与年龄相关的风险因素.
- 为临床决策提供有关T1 TSCC的LNM评估和治疗策略的信息.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (2005-2014) 中对2430名T1TSCC患者的回顾性分析.
- 应用单变量和多变量逻辑回归模型来评估年龄和LNM之间的关联.
- 进行了分层子组分析,以评估不同人口群体的年龄影响.
主要成果:
- 年轻的T1TSCC患者与老年患者相比,LNM的发病率明显高 (P < 0.01).
- 多变量分析显示,年龄较大独立地与LNM风险降低有关 (HR <1对于年龄较大的年龄组).
- 老年人对LNM的保护作用在大多数人口群体中是一致的,亚洲患者除外 (P <0.05).
结论:
- 患有T1TSCC的年轻人面临LNM的风险增加.
- 老年是T1TSCC中LNM的保护因素,尽管这种关联可能因种族而异.
- 加强LNM评估和考虑预防性部治疗对于优化年轻T1TSCC患者的治疗结果至关重要.
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