相关实验视频

Updated: Jun 18, 2025

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

一个3D全身人体温度调节模型来模拟手和脚的冷引起的血管扩张

Manpreet Singh¹, Jaques Reifman², Jose E Rubio¹

¹Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, Fort Detrick, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.

Computers in biology and medicine

|August 3, 2024

概括

这项研究通过结合寒冷诱导血管扩张 (CIVD) 来增强人体模型来预测感冒损伤. 改进的模型准确地预测皮肤温度,有助于防止极端环境中与寒冷有关的伤害.

科学领域:

人类生理学人类生理学
生物医学工程生物医学工程
环境健康环境健康

背景情况:

感冒引起的血管扩张 (CIVD) 是一种生理反应,对于预防手和脚等外围区域的感冒损伤至关重要.
准确预测寒冷应激的热反应对于理解和减轻寒冷伤害风险至关重要.

研究的目的:

通过结合一种新的CIVD机制配方来增强一个3D全身热调节人体模型.
为了提高人类在北极类环境中的热反应的预测准确度.

主要方法:

开发了一种新的现象学CIVD配方,基于皮肤环境热交换调节血流.
当核心体温下降到36.5°C以下时,CIVD被禁用.
校准和验证了模型,使用来自153名男性受试者的数据,在10种不同的冷暴露条件下进行校准和验证.

主要成果:

增强型号在皮肤温度上实现了根平均平方误差 (RMSE) <3.0°C,这与没有CIVD的模型相比是显著的改进.
整合CIVD可将皮肤温度预测错误降低高达3.6°C.
该模型对核心体温预测 (RMSE <0.2°C) 显示出高准确性,并将数据预测准确度提高了高达63%.

结论:

使用CIVD增强的温度调节模型提供了更准确的外围热应对寒冷压力的预测.
这种模型可以作为一个有价值的工具,用于制定指导方针,以尽量减少寒冷伤害风险,在长时间暴露于极端寒冷.

关键词:

寒冷的伤害伤害的伤害.暴露于冷空气中的暴露.感冒引起的血管扩张.沉浸在冷水中的沉浸.长时间暴露在寒冷中.热调节热调节热调节

更多相关视频

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

相关概念视频

Body Temperature

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...

Thermoregulation

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...

Thermosensation

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...