酸改性骨水泥的机械特征和细胞相容性,用于皮质水泥光盘塑
Salim Ghandour1, Linglu Hong1, Morteza Aramesh1
1Div. of Biomedical Engineering, Dept. of Materials Science and Engineering, Uppsala University, Sweden.
Journal of the mechanical behavior of biomedical materials
|August 3, 2024
概括
开发了一种新的低模块骨水泥 (hv-LA-PMMA) 用于微创脊柱手术,以减少老年患者骨折风险. 机械测试显示出有希望的结果,但需要进一步的生物相容性研究来临床使用.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 聚合物化学 聚合物化学
背景情况:
- 对于患有退行性磁盘疾病的老年患者来说,穿皮水泥磁盘整形 (PCD) 等微创脊柱治疗非常重要.
- 邻近的脊椎骨折 (AVF) 是PCD的重要风险,因为传统骨的硬度很高,特别是在骨质疏松患者中.
- 现有的低模块水泥没有优化,以满足光盘塑料的高粘度要求.
研究的目的:
- 开发和验证一种新型的低模块,高粘度聚甲基甲基甲酸 (PMMA) 骨水泥,其中包含酸 (LA),用于穿皮水泥光盘整形.
- 评估开发的hv-LA-PMMA水泥的机械性能,单体释放和细胞毒性.
- 确定hv-LA-PMMA对治疗退行性磁盘疾病的潜在临床应用的适用性.
主要方法:
- 合成12%体积的高粘度PMMA水泥. 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA). 亚麻酸 (hv-LA-PMMA).
- 机械测试包括压缩,压缩-张力疲劳,以及在PBS储存24周后评估模和压力强度.
- 在体外评估残留单体释放和细胞毒性使用纤维细胞暴露于水泥提取物在各种稀释和时间点.
主要成果:
- 与基础水泥相比,hv-LA-PMMA在扬氏模量 (36%) 和压力强度 (42%) 显著降低.
- 疲劳测试显示,平均疲劳极限为31,078个周期在5MPa,相当于磁盘环组织,优于其他低模块水泥.
- 细胞毒性测试表明,对照和hv-LA-PMMA提取物进行20倍稀释是必要的,以在7天内达到70%以上的纤维细胞活力,hv-LA-PMMA最初显示出更高的单体释放量.
结论:
- 开发的hv-LA-PMMA显示了皮穿式水泥光盘整形的有希望的机械性能,可能减轻AVF风险.
- 虽然机械性能令人鼓舞,但进一步的体内研究至关重要,以充分评估hv-LA-PMMA的长期生物相容性和临床疗效.
- 将酸添加到高粘度PMMA中提供了一个可行的策略,用于创建适合特定骨科应用的骨质水泥.
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