玻璃离子体水泥颗粒与赫西丁预反应:物理/化学特性和抗菌活性
Felipe Silva Gomes1, Paulo Vitor Campos-Ferreira1, Rayssa Ferreira Cavaleiro de Macedo1
1Dentistry Biomaterials Laboratory (Biomma), School of Dentistry, Federal University of Maranhão (UFMA), 65080-805, São Luís, MA, Brazil.
Journal of the mechanical behavior of biomedical materials
|August 3, 2024
概括
用赫西丁 (CHX) 功能化玻璃离子体水泥 (GIC) 增强了其抗菌性能和机械强度. 这种修改没有对离子释放,定时间或表面粗产生负面影响,使其成为一个有前途的牙科材料.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料工程 生物材料工程
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 玻璃离子水泥 (GIC) 是一种广泛使用的牙科修复材料.
- 将抗微生物药物纳入GIC可以通过预防二次虫病来提高其临床性能.
- 赫西丁 (CHX) 是一种广谱抗菌剂,具有GIC功能化的潜力.
研究的目的:
- 为了研究将预反应的赫西丁 (CHX) 纳入GIC颗粒的效果.
- 评估CHX功能化对GIC物理化学性质的影响.
- 评估CHX修饰的GIC对Streptococcus mutans的抗菌活性.
主要方法:
- 准备了四组GIC:对照组,GIC含有1%的CHX,2.5%的CHX和5%的CHX.
- 测试了机械性能 (凝聚力,弹性模量,微硬度).
- 分析了离子释放 (Ca+2,PO4-3,F-),表面粗度和定时间.
- 评估了对Streptococcus mutans的抗菌活性.
主要成果:
- 团队之间在弹性模量,粗度,定时间或离子释放方面没有发现显著差异.
- 与2.5%和5%CHX的GIC组相比,与对照组和1%CHX组相比,GIC组显示出明显更高的抗菌活性.
- 5%的GIC-CHX组表现出最高的微硬度和凝结强度.
结论:
- 预反应的CHX成功地赋予GIC抗菌活性,而不影响关键的物理化学性质.
- CHX功能化改善了GIC的凝聚力和微硬度.
- 这些发现表明,CHX修饰的GIC是增强牙科修复的可行选择.
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