在英格兰试点基于废水的诺罗病毒监测
David I Walker1, Jessica Witt1, Wayne Rostant1
1Centre for Environment, Fisheries and Aquaculture Science, Weymouth, Dorset, UK.
Water research
|August 3, 2024
概括
在英格兰,基于废水的流行病学成功监测了诺罗病毒 (GI和GII). 废水中诺罗病毒水平与报告的病例相关,这表明它有社区监测的潜力.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生监督是对公共卫生的监督.
- 传染病流行病学 传染病流行病学
背景情况:
- 基于废水的流行病学 (WBE) 证明对COVID-19监测有价值.
- 对将WBE应用于其他重要病原体的兴趣越来越大.
- 在全球范围内,诺罗病毒仍然是一个主要的公共卫生问题.
研究的目的:
- 量化英格兰废水中的诺罗病毒基因组I (GI) 和II (GII).
- 评估WBE对跟踪诺病毒趋势和疫情的有用性.
- 探索废水中诺罗病毒水平与报告的临床病例之间的关系.
主要方法:
- 重新分析了大约3200个废水样本,这些样本先前收集用于SARS-CoV-2.
- 使用已建立的WBE技术量化诺罗病毒GI和GII.
- 统计分析包括相对强度指数 (RSI) 和当地莫兰的I.
主要成果:
- 分别在93%和98%的样本中检测到GI和GII;99%的样本至少包含一个基因组.
- 诺罗病毒的度随着时间和地理位置的变化而变化,在某些地区,胃肠道疾病的患病率增加.
- 废水中诺罗病毒水平与报告病例数量有显著的线性相关性,并确定了局部爆发.
结论:
- WBE是一种可行的和有效的工具,用于监测社区中诺病毒的流通.
- WBE数据可以补充对诺罗病毒的传统监测方法.
- 该研究强调了WBE在支持对诺罗病毒爆发的公共卫生反应方面的潜力.
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