链接北上腺素的生产和表现,以饮食诱导的低度,慢性炎症在牛肉的肠道
Michael H Kogut1, J Allen Byrd1, Kenneth Genovese1
1Southern Plains Agricultural Research Center, USDA-ARS, College Station, TX, USA.
Poultry science
|August 3, 2024
概括
一种高非粉多糖 (NSP) 的饮食增加了 brojlers的肠道诺拉上腺素 (NOR),导致炎症和性能降低. 这突出了神经免疫通路作为改善家禽健康的目标,而无需使用抗生素.
科学领域:
- 禽类的营养和生理学
- 胃肠道免疫学 胃肠道免疫学
- 神经胃肠病学 神经胃肠病学
背景情况:
- 抗生素增长促进剂 (AGPs) 用于维持家禽的肠道健康.
- 移除AGPs导致人们担心饮食引发的慢性肠道炎症.
- 使用高非粉多糖 (NSP) 的饮食模型被开发用于研究 brojlers的低级肠道炎症.
研究的目的:
- 为了调查慢性肠道炎症会增加神经化学分泌的假设,激活免疫细胞和损害肉的表现.
- 确定高NSP饮食对肉生长,料转化和肠道神经化学的影响.
主要方法:
- 肉被养为控制的玉米-大豆饮食或高NSP饮食 (30%的米).
- 鸟类的体重,料转换和便样本是在7日,14日,21日和28天后收集的.
- 用超高性能液态染色学 (UHPLC) 分析了十二指肠和肠组织和内容,以确定神经化学度.
主要成果:
- 根据UHPLC的分析显示,高NSP饮食养的鸟类的肠道和便中的诺拉上腺素 (NOR) 含量显著增加.
- 经过1至14天的时间内,没有观察到体重增加或料转换的差异.
- 从14到28天后,高NSP饮食的鸟类显著减少体重增加和料转换.
结论:
- 饮食诱导的慢性肠道炎症会增加肠道诺尔上腺素 (NOR) 的产生.
- 升高的NOR会对肉的表现产生负面影响,这表明神经免疫通路的作用.
- 准神经免疫通路为管理肠道炎症和改善无AGP的家禽生产提供了潜在的策略.
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