通过基因素脱乙烯化排除核细胞重塑器,强制执行异色染色沉默和表观遗传遗传

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Updated: Jun 18, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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Rakesh Kumar Sahu1, Jothy Dhakshnamoorthy1, Shweta Jain1

  • 1Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Molecular cell
|August 3, 2024
PubMed
概括

通过激素脱乙酶 (HDACs) 的基因脱乙化保持了基因沉默,通过阻断SWI/SNF重塑剂来保持异性染色体中的基因沉默. 这确保了稳定的表观遗传,为基因组调节和疾病提供了洞察力.

关键词:
H3K9me3是什么意思 H3K9me3是什么意思在RSC上使用RSC.在 SWI/SNF 中.染色体重塑 染色体重塑的方法表观遗传遗传是一种表观遗传遗传.基因沉默是对基因进行沉默的方法.异性染色是一种异性染色.基因素脱乙化 基因素脱乙化基质子的修改 基质子的修改读写的读写方式

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