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Updated: Jun 18, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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在癌症中准MHC-I内体-解体贩运途径:从机制到免疫疗法

Di Ye1, Shuang Zhou1, Xinyu Dai1

  • 1Division of Abdominal Cancer, Department of Medical Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.

Biochimica et biophysica acta. Reviews on cancer
|August 3, 2024
PubMed
概括

瘤细胞通过减少表面主要基因相容性复合物I类 (MHC-I) 表达来逃避免疫检查点阻塞 (ICB) 治疗. 了解MHC-I lysosomal降解为提高癌症免疫疗法的有效性提供了新的策略.

关键词:
CD8 (((+) 细胞毒性T细胞这是内分体-解体贩运.免疫检查站封锁免疫检查站封锁免疫逃逸是一种免疫逃避.主要组织相容性复合物I类.

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