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Published on: November 19, 2012

在TBI后,RAGE调解海马细胞周细胞反应和神经血管单元损伤

Minghao Du¹, Jiani Li², Sixun Yu³

¹Department of Neurosurgery, The General Hospital of Western Theater Command, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China; Mini-Invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University, Xi'an 710003, China.

Experimental neurology

|August 3, 2024

概括

创伤性脑损伤通过细胞RAGE激活损害了血脑屏障. 在受伤后早期阻止这种受体可以改善神经功能,并减少海马的损伤.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
病理学病理学病理学

背景情况:

创伤性脑损伤 (TBI) 损害了大脑功能,皮质细胞的改变影响了神经血管完整性.
创伤损伤对海马细胞的具体影响以及高级糖化最终产品受体 (RAGE) 信号传递的作用仍在调查中.

研究的目的:

为了研究RAGE激活在TBI后对海马内皮质细胞的影响.
确定RAGE阻塞能否保护神经功能并减轻TBI引起的损伤.

主要方法:

在TBI后的小鼠海马体中评估PDGFR-β,NG2和HMGB1-S100B/RAGE通路表达.
使用免疫光和传输电子显微镜测量了血脑屏障 (BBB) 的完整性.
利用RAGE淘汰赛小鼠和RAGE抑制剂FPS-ZM1来评估治疗潜力.

主要成果:

在TBI后很早发生了海马体周细胞中与RAGE相关的BBB损伤.
抑制RAGE显著改善了BBB完整性,减少了周血管,并增强了血管底膜和紧密的结点数.
愤怒阻塞保护神经功能,行为测试和双皮质染色证明了这一点.

结论:

皮细胞中的HMGB1-S100B/RAGE轴与TBI早期的神经血管单元 (NVU) 损伤有很强的相关性.
在TBI后,Pericyte RAGE代表了保护神经功能的关键治疗标.

关键词:

在CCI中,你会发现 CCI.这就是HMGB1的特点.这是NVU的NVU.危险细胞 (Pericyte) 是一种危险细胞.愤怒的愤怒愤怒的愤怒在S100B中,我们可以使用S100B.

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