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化物诱导肝肠损伤和维生素B减轻通过调节IL-17A和Bifidobacterium在阴茎中的作用
Chen Liang1, Cuicui Zhuang2, Chenkai Cheng2
1College of Animal Science, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China.
过度的化物通过破坏胆酸调节和肠道微生物群来损害肝脏和肠道. 维生素B2和Bifidobacterium补充剂在逆转这种化物诱导的损害方面显示出希望.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 毒理学 毒理学 毒理学
- 微生物组研究 微生物组研究
背景情况:
- 化症是一种广泛的公共卫生问题,由过度化物暴露引起.
- 化物毒性显著影响肝脏和肠道健康,但潜在的机制和治疗方法尚未完全理解.
研究的目的:
- 调查化物诱导的肠肝损伤的机制.
- 探索维生素B2在减轻化物毒性的治疗潜力.
主要方法:
- 使用IL-17A淘汰和野生型小鼠模型暴露在化物和/或维生素B2的环境中.
- 评估肝脏和肠道形态/功能,胆酸代谢 (包括FXR-FGF15信号传导) 和胆管微生物组组成 (16S rDNA).
- 在单独的小鼠模型中研究了Bifidobacterium补充剂的影响.
主要成果:
- 化物暴露诱导肝肠道损伤和肠肝循环障碍通过改变胆酸合成,运输和FXR-FGF15通路.
- 膜对化物最敏感,微生物组发生了显著的变化,特别是Bifidobacterium的减少.
- 维生素B2和Bifidobacterium补充剂改善了化物诱导的损伤,并恢复了肠肝循环.
结论:
- 化物会损害肝脏和肠道功能,并通过胆酸和FXR-FGF15通路失调扰乱肠肝循环.
- 维生素B2通过调节IL-17A通路和乳腺微生物群来减轻化物毒性.
- 补充Bifidobacterium有效地逆转化物诱导的肝肠损伤,突出其治疗化症的治疗潜力.
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