在诊断40年后,患有异常学脊椎病的患者的肺功能
Lærke C Ragborg1, Casper Dragsted1, Søren Ohrt-Nissen1
1Department of Orthopedic Surgery, Spine Unit, Rigshospitalet, Copenhagen, Denmark.
概括
与普通人群相比,患有异常学脊椎病 (IS) 的成年人表现出正常的长期肺功能 (PF). 然而,胸部曲线与减少PF有关,尽管仍在正常范围内,这表明目前治疗指南的良好结果.
科学领域:
- 肺部医学 肺部医学
- 整形外科 整形外科 整形外科
- 脊柱形研究 脊柱形研究
背景情况:
- 异形脊椎病 (IS) 可以影响肺功能,可能导致严重病例的残疾和死亡.
- 关于成年IS患者长期肺功能的数据有限.
- 由于人们对通风功能的担忧,因此需要对成年人进行全面评估.
研究的目的:
- 为了评估长期肺功能 (PF) 在成年异常学脊椎病 (IS) 患者.
- 将IS患者的PF与年龄相匹配的普通人群进行比较.
- 使用扩展性肺功能测试 (EPFT) 进行详细评估.
主要方法:
- 对177名在1972年至1983年期间被诊断为IS的患者进行了回顾性临床后续研究.
- 77名符合条件的IS患者接受了临床检查,放射和EPFT.
- EPFT包括FVC,FEV1,TLC,DLco;结果分析使用与规范数据相对的z-score.
主要成果:
- 在77名成年IS患者中没有检测到整体肺功能障碍 (平均年龄为54.6岁,随访时间为40.8年).
- 吸烟者 (当前/以前) 是唯一一个z-score低于正常限度的群体.
- 与胸部/腰部曲线相比,胸部IS曲线患者的FEV1,FVC,TLC和DLco的绝对和z-score平均值较低,但在正常范围内.
结论:
- 成年IS患者与EPFT进行评估时,与普通人群相比,长期肺功能正常.
- 与TL/L曲线相比,胸部IS曲线与肺功能减弱有关,但仍在正常范围内.
- 目前对IS的治疗指南允许患者期望与普通人群相比的长期肺功能.
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