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Updated: Jun 18, 2025

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循环时钟组件PER2在性结肠炎中负面调节CD4+T细胞IFN-γ的产生

Yulan Ye1, Changqin Liu2, Ruijin Wu2

  • 1Center for IBD Research and Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China; Department of Gastroenterology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou 215008, China.

Mucosal immunology
|August 3, 2024
PubMed
概括

昼夜钟蛋白PER2在性结肠炎 (UC) CD4+ T细胞中降低,影响疾病的严重程度. 恢复PER2通过降低ADAM12的调节来抑制炎症,这表明PER2是UC的治疗点.

关键词:
一个解体和金属蛋白酶12的解体.CD4 (((+) T 细胞 细胞在IFN-γ中使用IFN.周期昼夜时钟 2 周期昼夜时钟 2性结肠炎是一种

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