追赶增长是否会带来认知成本? 认知结果和成长模式在成长不一致的同卵双胞胎
Jeanine M M van Klink1, Erik W van Zwet2, Enrico Lopriore1
1Neonatology, Willem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
The Journal of pediatrics
|August 3, 2024
概括
胎儿生长限制 (FGR) 本身,而不是产后追赶生长 (CUG),会对单双胞胎的认知发展产生负面影响. 这项研究强调FGR是影响认知结果的主要因素.
科学领域:
- 发育生物学是发展生物学.
- 儿科神经学 儿科神经学
- 双胞胎研究是关于双胞胎的研究.
背景情况:
- 胎儿生长限制 (FGR) 是影响长期健康的一个重大问题.
- 对FGR异调的单胆双胞胎为研究生长影响提供了一个独特的模型.
- 在减轻FGR效应方面,产后追赶增长 (CUG) 的作用受到辩论.
研究的目的:
- 区分FGR与CUG对认知结果的影响.
- 为了研究具有选择性FGR的单双胞胎的认知发展.
- 分析早期生长模式与神经发育之间的关系.
主要方法:
- 选择性FGR (3-17岁) 的单双胞胎LEMON研究队列的分析.
- 增长测量和神经发育测试 (FSIQ) 的回顾性收集.
- 多变量回归和概括估计方程,以评估FSIQ,出生体重z-score,妊娠年龄和2岁时的CUG之间的关联.
主要成果:
- 出生体重z-score和出生时的妊娠年龄与更高的FSIQ有显著的关联.
- 在对出生因素进行调整后,2岁的早期产后追赶增长 (CUG) 与FSIQ没有显著关联.
- 由出生体重z-score表示的FGR本身显示出与认知结果的显著关联.
结论:
- 胎儿生长限制 (FGR) 本身,而不是早产后追赶生长 (CUG),对认知发育有负面影响.
- 研究结果支持FGR作为受影响双胞胎神经发育轨迹的关键决定因素.
- 这项研究强调了解决FGR以优化认知结果的重要性.
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