长期视觉结果和液体区的变化在有限的早期与早期响应对糖尿病黄斑的抗VEGF治疗
Christian Akotoye1, Scott W Perkins2, Neha Sharma3
1Case Western Reserve University School of Medicine, Cleveland, OH.
概括
与早期响应者 (ER) 相比,在抗VEGF注射后,有限的早期响应者 (LER) 显示出更好的长期视力敏度和中央子场厚度结果. 需要进一步的研究来优化治疗以持续改善视力.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗视网膜 医学视网膜
背景情况:
- 抗VEGF治疗是各种视网膜疾病的基石治疗.
- 患者对抗VEGF治疗的反应可能有很大差异,需要对响应者进行分类.
- 了解不同患者应答组的长期结果对于治疗优化至关重要.
研究的目的:
- 评估和比较最好的视力敏度 (BVA) 和中央子场厚度 (CST) 结果在24个月和36个月之间,在有限的早期响应者 (LER) 和早期响应者 (ER) 之间进行抗VEGF注射.
- 基于初始反应模式,分析抗VEGF治疗的长期疗效.
主要方法:
- 对112名用抗VEGF注射治疗的患者进行了回顾性图表审查.
- 患者在注射后3个月被分类为LER (解剖学或视觉标准未满足早期反应) 或ER.
- 统计分析包括Welch的t测试和多变量回归来比较36个月的BVA和CST变化.
主要成果:
- 在组合LER (cLER) 和组合ER (cER) 组以及视觉LER (vLER) 和视觉ER (vER) 组之间观察到3个月后BVA变化的显著差异 (p <0.05).
- 与cLER组相比,cER组的BVA从3个月到36个月下降幅度更大.
- 与ER对应组相比,LER组在统计学上显著地显示出更大的CST减少 (p < 0.01).
结论:
- 长期抗VEGF治疗显示出价值,LER患者在CST减少方面显示出更有利的结果.
- 虽然BVA变化在LER和ER组之间有所不同,但超过3个月的持续改善需要进一步调查.
- 识别和理解LER和ER表型对于预测长期治疗成功和探索新型治疗策略至关重要.
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