抗瘤治疗中的心血管毒性:生物和治疗见解
Xuwen Lin1, Xidong Ma1, Sheng Zhao2
1Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Trends in cancer
|August 3, 2024
概括
免疫治疗,化疗,向治疗和放射治疗等癌症治疗可以导致心脏问题. 了解这些机制是预防和治疗癌症治疗引起的心血管毒性的关键.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗瘤疗法改善了癌症存活率.
- 这些治疗方法可能会导致严重的心血管毒性.
- 了解这些毒性的机制对于患者管理至关重要.
研究的目的:
- 审查各种抗瘤疗法诱导的心血管毒性的生物机制.
- 探索这些毒性的临床预防和治疗策略.
主要方法:
- 关于免疫治疗,化疗,向治疗和放射治疗对心血管系统的影响的文献综述.
- 分析涉及治疗相关心脏毒性的分子和细胞通路.
主要成果:
- 免疫疗法:由免疫细胞和细胞因子介导.
- 化疗:通过自断和线粒体功能障碍引起损伤.
- 向疗法:通过内甲素-1 (ET-1) 和心脏信号干扰诱导毒性.
- 放射治疗:通过影响内皮细胞,炎症和动脉样硬化,导致心肌病和纤维化.
结论:
- 心血管毒性是现代癌症治疗的一个重要问题.
- 阐明每个治疗类型的特定机制是必不可少的.
- 制定有针对性的预防和治疗策略对于改善患者的治疗结果至关重要.
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