综述:具有肌源性分化潜力的畜牧细胞类型:培养肉类发展的考虑因素
M Olenic1, C Deelkens2, E Heyman3
1Tissue Engineering Lab, Department of Development and Regeneration, KU Leuven Campus Kulak, Kortrijk, Belgium; Veterinary Stem Cell Research Unit, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Animal : an international journal of animal bioscience
|August 3, 2024
概括
培养肉类生产探索使用动物细胞来减少环境影响和改善福利. 本综述考察了细胞类型,如肌细胞和干细胞,用于开发细胞农业,重点关注肌细胞分化.
科学领域:
- 细胞农业 细胞农业
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
背景情况:
- 人们越来越担心传统畜牧业和动物福利对环境的影响.
- 对替代蛋白质来源和可持续食品生产方法的兴趣日益增加.
- 细胞农业的潜力是通过培养动物细胞以获得食物来应对这些挑战.
研究的目的:
- 审查和总结在培养肉类开发中使用的各种农场动物细胞类型.
- 分析不同细胞来源的优点和局限性,包括介质细胞,肌细胞和多能干细胞.
- 评估影响细胞表现的因素,如细胞源选择和培养条件,重点关注肌体差异化.
主要方法:
- 关于细胞农业和培养肉类当前研究的文献综述.
- 对通常用于培养肉生产的细胞类型的分析.
- 评估不同细胞群的肌原分化能力和繁殖潜力.
- 考虑细胞培养条件及其对细胞性能的影响.
主要成果:
- 肌细胞 (卫星细胞) 由于其肌性能力,经常用于培养肉类,但其增殖能力有限.
- 目前正在研究中介细胞 stromal 细胞和多能干细胞,以改进肌源性分化协议.
- 介酶体 stromal 细胞和多能干细胞的多能性为开发各种肉组织 (肌肉,脂肪,结合性) 提供了潜力.
结论:
- 选择合适的细胞类型和优化的培养条件对于高效的培养肉的开发至关重要.
- 需要进一步研究介质细胞 stromal 细胞和多能干细胞的肌体差异化协议.
- 细胞农业有望实现可持续和道德的肉类生产.
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