在同一个成年人中,多种疫苗的比较揭示了疫苗特异性和与年龄相关的幽默反应模式:一个开放的IV期试验
Marieke van der Heiden1, Sudarshan Shetty1, Elske Bijvank2
1Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The Netherlands.
Nature communications
|August 3, 2024
概括
年龄较大的成年人对疫苗反应减少,特别是对初级肺炎球菌和COVID-19疫苗的反应减少. 一部分老年男性对多种疫苗的反应较低,有助于针对性的疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在老年人中,疫苗的有效性通常会下降,因此需要对与年龄相关的免疫反应进行研究.
- 了解低疫苗反应率对于开发有效的免疫策略对于老龄化人口至关重要.
研究的目的:
- 研究不同成年年龄组对多种疫苗的幽默免疫反应.
- 确定与老年人免疫反应低相关的因素和特征.
主要方法:
- 在四价流感 (QIV),13价肺炎球菌联合体 (PCV13) 和SARS-CoV-2 mRNA-1273疫苗接种后,对幽默性免疫反应 (血液凝结抑制标位和抗体度) 的分析.
- 在6个月后,在年轻成人,中年和老年成人参与者 (n=315) 中,对免疫反应和抗体持久性的比较.
主要成果:
- 辅助QIV疫苗接种在所有年龄组都产生了类似的H3N2标位.
- 初级PCV13和mRNA-1273疫苗接种导致老年人抗体度较低,与年轻人相比.
- 在所有测试的疫苗中,老年人的幽默反应持续时间较短.
- 大约10%的参与者,主要是年长的男性,对多种疫苗的反应很低.
结论:
- 老年人表现出抗体度降低,并在初级肺炎球菌和COVID-19疫苗接种后持续时间较短.
- 鉴定疫苗反应较低的人群,特别是年长的男性,有助于制定有针对性的疫苗接种策略,以改善老年人群感染传染病的保护.
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