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血清A-FABP水平的初始和变化的关联与前症的发展和改善

Tingting Hu¹, Yiting Xu¹, Xiaoya Li¹

¹Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.

The Journal of clinical endocrinology and metabolism

|August 3, 2024

概括

血清脂肪细胞脂肪酸结合蛋白 (A-FABP) 水平的升高与先前缩症的发病率更高有关. 在A-FABP的变化也预测了前症的发展和改善,强调其在肌肉健康中的作用.

科学领域:

老年学是一门学科.
代谢过程中的代谢.
肌肉生理学肌肉生理学

背景情况:

横截面研究表明,血清脂肪细胞脂肪酸结合蛋白 (A-FABP) 和前性之间存在联系.
对A-FABP对前症发病率和改善的影响的纵向数据有限.

研究的目的:

调查血清A-FABP水平与社区队列中前症的发生率和改善之间的关联.
为了检查血清A-FABP水平随时间的变化如何与前缩症的发展和逆转有关.

主要方法:

一项对1496名成年人进行的纵向队列研究,追踪时间约为2.1年.
血清A-FABP水平,内脏脂肪面积 (VFA) 和骨肌肉指数 (SMI) 在基线和随访时被测量.
预沙尔科白症的定义是基于SMI相对于性别特定的年轻基准平均值.

主要成果:

较高的血清A-FABP基线水平与增加的前症发病率 (RR 3.22-2.11) 和改善的减少 (RR 0.66-0.71) 相关.
血清A-FABP水平的变化提供了关于前缩症发病率和改善的独立预测信息.
关联保持一致,无论骨肌肉质量是否以体重或VFA标准化.

结论:

基线血清A-FABP水平及其变化都是预沙症的显著预测因素.
升高的A-FABP与患上前症的风险更高,改善的机会更低有关.
血清A-FABP是一种潜在的生物标志物,用于监测和管理先前缩症.

关键词:

脂肪酸结合蛋白质的脂肪细胞.改进是一种改善.发生率的发生率.纵向变化的纵向变化这种疾病是前沙copenia.

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