患者报告的异性食道炎的症状和负担:来自现实世界的临床实践的证据
Xiao Xu1,2, Justin Kwiatek3, James Siddall4
1BioPharmaceuticals Market Access and Pricing, AstraZeneca, 200 Orchard Ridge Dr, Gaithersburg, MD, 20878, USA. Xiao.Xu1@astrazeneca.com.
BMC gastroenterology
|August 3, 2024
概括
性食道炎 (EOE) 显著影响生活质量,即使有治疗. 一项研究发现36%的患者患有持续性消化不良,这突显了需要更好的EoE疗法.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 患者报告的结果.
背景情况:
- 性食道炎 (EoE) 是一种慢性食道炎症状况.
- 关于EoE临床特征和疾病负担的真实数据至关重要.
- 了解治疗挑战,特别是持续性消化障碍,是关键.
研究的目的:
- 描述EoE的临床特征和疾病负担.
- 为了分析一小组经历了EoE患者的治疗,尽管经历了治疗.
- 为改进开放式教育管理策略的制定提供信息.
主要方法:
- 2020年在美国和欧盟对患者和医生的调查.
- 包括12岁以上的患有被诊断为EoE (≥15种乙酸/HPF) 的患者在治疗中.
- 整体EoE群体与尽管接受治疗但患有食障碍的子组进行比较.
主要成果:
- 包括1001名患者;36%的患者尽管接受了治疗,但仍患有食不适症.
- 缺食症 (86%) 和胃炎 (49%) 是缺食症小组中常见的症状.
- 尽管接受了治疗,但患有失消的患者报告了更多的症状日和对日常生活和心理健康的影响.
结论:
- EoE会引起严重的症状和并发症,影响患者的福祉.
- 持久性消化不良是相当大一部分EoE患者的一个重要问题.
- 迫切需要提高对EdE的认识和新的治疗方法.
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