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重建算法对半定量测量的效应在F-FDG PET/CT成像中
Filiz Özülker1, Gündüzalp Buğrahan Babacan, Safiya Cengiz
1University of Health Sciences, Prof. Dr. CemilTaşcıoğlu Hospital, Department of Nuclear Medicine, İstanbul, Turkey. fozulker@gmail.com.
Hellenic journal of nuclear medicine
|August 4, 2024
概括
在18F-FDG PET/CT成像中的不同重建算法,如Q.Clear和OSEM与TOF/PSF,显著影响半定量测量,可能导致对恶性瘤治疗反应的误解.
科学领域:
- 核医学就是核医学.
- 医疗成像医学成像
- 放射化学 放射化学是指辐射化学.
背景情况:
- -18-氧葡萄糖 (18F-FDG) 阳离子发射断层扫描/计算机断层扫描 (PET/CT) 对于评估恶性疾病至关重要.
- 重建算法和像飞行时间 (TOF) 和点传播函数 (PSF) 这样的参数影响图像质量和定量准确性.
研究的目的:
- 调查不同重建算法 (Q.Clear,OSEM) 和参数 (TOF,PSF) 对18F-FDG PET/CT.半定量测量的影响.
- 根据重建方法评估标准化摄入值 (SUV),代谢瘤体积 (MTV) 和总损伤糖解 (TLG) 的变化.
主要方法:
- 分析了264名已知或可疑患有恶性疾病的患者的原始PET数据.
- 数据使用Q.Clear,OSEM,有或没有TOF和PSF (SharpIR®,VUE Point FX®) 来重建数据.
- 半定量参数包括SUVmax,SUVmean,SUVpeak,MTV和TLG在参考结构 (肝脏,中) 和病变中进行测量.
主要成果:
- 与其他算法相比,β350+ToF重建方法始终产生更高的SUVmax和SUV平均值.
- 基于OSEM的重建 (OSEM+ToF,OSEM+TOF+PSF) 导致病变的SUV值比β350+ToF.比统计学上显著更低.
- β350+ToF表现出最高的病变与背景比率 (L/AP SUVmax,L/AP SUVmean),特别是在恶性病变中.
结论:
- 重建算法和参数的选择显著影响18F-FDG PET/CT中的半定量测量.
- 不同方法的结果差异可能导致在瘤成像中误解治疗反应.
- 重建协议的标准化对于可靠和可重复的PET/CT定量分析至关重要.
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