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Updated: Jun 18, 2025

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

An Automated Radiosynthesis of [⁶⁸Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

使用Ga-FAPI-46 PET/CT检测各种癌症类型的初始临床经验

Habibollah Dadgar¹, Nasim Norouzbeigi, Majid Assadi

¹Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran. habib.zaidi@hcuge.ch.

Hellenic journal of nuclear medicine

|August 4, 2024

概括

加-68标记纤维细胞激活蛋白抑制剂 (Ga-FAPI) PET/CT扫描显示优异的癌症检测与许多癌症的F-FDG PET/CT相比. 需要进一步的试验来证实这些发现的Ga-FAPI-46疗效.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

⁶⁸Ga-FAPI PET/CT提供高瘤内标记物吸收和低背景,使得癌症微环境病变的清晰可视化.
⁶⁸Ga-FAPI-46是一种新型的标记物,与已建立的癌症评估方法进行比较.

研究的目的:

为了在各种癌症中比较新型Ga-FAPI-46 PET/CT与常规F-FDG PET/CT和其他标记剂 (Ga-DOTATATE,Ga-Pentixafor) 的诊断疗效.
评估Ga-FAPI-46适用于检测癌症复发和转移的适用性.

主要方法:

追溯分析了11名患有经遗传学确认的癌症的患者,包括腺癌,MTC,PTC,宫,胃,GBM,结肠,尤文肉瘤和乳腺癌.
使用F-FDG,Ga-FAPI,Ga-DOTATATE和Ga-Pentixafor进行了PET/CT扫描.
图像分析包括用于癌症检测的视觉评估和使用SUVmax和TBR用于复发和转移的半定量分析.

主要成果:

68Ga-FAPI-46检测到的转移 (淋巴结,肝脏,骨头) 比F-FDG.18更多.
与Ga-FAPI-46相比,与F-FDG.18相比,观察到淋巴结和骨转移的SUVmax和TBR值显著更高.
在肝转移方面,Ga-FAPI-46的TBR显著高于F-FDG的18,尽管SUVmax是可比的.

结论:

在乳腺,胃肠道,妇科,PTC和MTC方面,Ga-FAPI PET/CT通常表现优于F-FDG PET/CT.
Ga-FAPI PET/CT 不适用于评估GBM和尤文肉瘤.
需要进行更大规模的临床试验,以验证Ga-FAPI-46疗效的初步发现.

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