甲状腺过氧化酶抗体和没有甲状腺过氧化酶抗体的亚临床甲状腺功能低下症的妊娠结果 - 一项前性队列研究
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R Priyanka1, Haritha Sagili2, Jayaprakash Sahoo3
1Department of Obstetrics and Gynaecology, JIPMER, Puducherry, India. priyankarajandran00187@gmail.com.
Archives of gynecology and obstetrics
|August 4, 2024
概括
怀孕期间的亚临床甲状腺功能低下症 (SCH) 可能导致新生儿重症监护室入院的增加. 然而,轻度的SCH和甲状腺过氧化酶抗体 (TPOAb) 并没有显著影响大多数孕产妇和周围产生的结局.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间的亚临床甲状腺功能低下症 (SCH) 与不良的胎儿和母亲的结果有关.
- 关于轻度SCH (TSH 2.5-4 mIU/L) 的妇女的孕产妇和产周结局的数据有限.
研究的目的:
- 为了比较患有SCH的妇女和euthyroid孕妇之间的怀孕结果.
- 为了确定甲状腺过氧化酶抗体 (TPOAb) 在SCH.妇女的患病率.
- 评估TPOAb阳性对胎儿和母亲结果的影响.
主要方法:
- 在第一季度招募了178名孕妇.
- 乙甲状腺:TSH 0.1-2.4 mIU/L;SCH:TSH 2.5-4 mIU/L. 甲状腺:TSH 0.1-2.4 mIU/L. 甲状腺:TSH 2.5-4 mIU/L. 甲状腺:TSH 0.1-2.4 mIU/L.
- SCH女性进行了TPOAb测试;所有结果都被评估到分娩.
主要成果:
- 在SCH组中,超重/肥胖女性的比例更高 (83.51%与68%).
- 新生儿重症监护室 (NICU) 的入院率在SCH组显著更高 (aOR:3.24).
- 与TPOAb阴性女性相比,TPOAb阳性SCH女性的妊娠糖尿病,子宫内生长迟缓,死胎和低APGAR分数的发病率更高.
结论:
- 在SCH和euthyroid妇女之间,怀孕结果是相似的,除了SCH组的NICU入院增加.
- 在SCH中TPOAb阳性可能与特定的不良结果有关.
- 需要进一步进行大规模的前性研究,以澄清SCH.妇女的怀孕结果.
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