玻璃化卵子和由它们衍生的早期胚胎之间的表观遗传学修饰:叙述性审查
Mostafa Saeedinia1, Jiayi Chen2, Omid Kohandel Gargari3
1Shahid Beheshti University of Medical Sciences, Tehran, Iran. mostafasaeediniya627@gmail.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|August 4, 2024
概括
在辅助生殖技术 (ART) 中的玻璃化可能会由于表观遗传变化影响胚胎质量. 本综述检查了玻璃化卵细胞和胚胎中的DNA,RNA和基因素修饰.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 低温生物学 低温生物学
背景情况:
- 玻璃化是辅助生殖技术 (ART) 中的一个关键技术,用于冷保存卵子和胚胎.
- 冷保存程序可以诱导环境变化,引发人们对表观遗传修饰的担忧.
- 表观遗传变化可能会影响胚胎的质量和发育潜力.
研究的目的:
- 综合审查冷保存,特别是玻璃化对卵细胞和胚胎的影响.
- 评估现有的关于玻璃化卵细胞和早期胚胎表观遗传修饰的文献.
- 在与ART相关的玻璃化中调查DNA修饰,RNA甲基化,基因素修饰和microRNAs.
主要方法:
- 关于卵细胞和胚胎玻璃化研究的文献综述.
- 分析研究报告的冷保存后基因组状况的变化.
- 对各种表观遗传标记 (DNA,RNA,基因组,microRNAs) 的发现进行综合.
主要成果:
- 在ART中的玻璃化程序与卵细胞和胚胎的基因组状况的变化有关.
- 报告的表观遗传修饰包括DNA甲基化,RNA甲基化和基因素修饰的改变.
- 微RNA表达模式也可能受到玻璃化的影响.
结论:
- 在ART中的玻璃化引发了对卵细胞和胚胎潜在的不良表观遗传后果的担忧.
- 需要进一步的研究才能充分理解和减轻玻璃化对表观遗传的影响.
- 解决这些表观遗传变化对于提高辅助生殖技术的质量和成功率至关重要.
相关概念视频
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
02:07Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K