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对T1结肠直肠癌的管理

Hidenori Tanaka¹, Ken Yamashita², Yuji Urabe²

¹Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan, hitanaka@hiroshima-u.ac.jp.

|August 4, 2024

概括

内镜切除可以治疗具有淋巴结转移 (LNM) 的低风险T1结直肠癌 (CRC). 高风险病例需要手术切除,但新的诊断工具旨在减少T1CRC患者不必要的手术.

科学领域:

胃肠病学胃肠病学
手术瘤学手术瘤学
病理学病理学病理学

背景情况:

粘膜下侵袭性 (T1) 大肠直肠癌 (CRC) 具有10%的淋巴结转移 (LNM) 风险.
组织病理因素,如入侵深度和等级分层T1 CRC中的LNM风险.

研究的目的:

评估基于LNM风险的T1 CRC管理策略.
探索内镜切除 (ER) 和手术切除 (SR) 在T1CRC治疗中的作用.
突出用于识别低风险T1CRC的新型诊断技术.

主要方法:

对LNM风险分层的组织病理因素的审查.
在T1 CRC中分析ER与SR的结果.
探索LNM检测的新兴诊断技术 (名录,人工智能,基因组学).

主要成果:

通过ER进行局部切除可以治愈低风险的T1CRC.
高风险的T1CRC需要SR与淋巴结解剖.
新的诊断方法旨在识别更多适合ER的T1CRC病例.

结论:

具有负边缘的完整切除对于T1 CRC中的ER至关重要.
先进的ER技术促进了完全切除.
对T1CRC的治疗决定必须平衡LNM风险与患者因素.

关键词:

内镜切除术是一种内镜切除术.淋巴结转移是淋巴结的转移.手术切除手术切除的方法 T1 大肠直肠癌

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