对血阿尔多斯特的校正提高了重复定时尿样的准确性,用于估计饮食摄入量
Anne Myrthe C van Vliet1,2, Liffert Vogt3,4, Bigina N R Ginos3,4
1Nephrology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands, a.m.vanvliet@amsterdamumc.nl.
Kidney & blood pressure research
|August 4, 2024
概括
经过多次定时尿液采集,并对血中阿尔多斯特进行校正,可以比单个24小时尿液样本更准确地评估每日摄入量. 这种提高的准确性对于长期的平衡研究至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 平衡受阿尔多和皮质醇的环平律的影响,影响组织的储存和释放.
- 由于这些动态过程,一次24小时尿液采集可能无法可靠地估计个人摄入量.
研究的目的:
- 评估重复定时尿液采集的准确性,以估计每日摄入量.
- 为了确定用血中阿尔多素测量对这些采集进行校正是否能提高准确性.
主要方法:
- 一项对16名健康男性进行的代谢病房研究后期分析,这些男性接受固定的饮食 (50或200毫摩尔/天).
- 每天在四个时间间隔收集尿液 (7:00-13:00, 13:00-19:00, 19:00-23:00, 23:00-07:00小时).
- 每天在三个时间点测量血阿尔多素;在5-7天使用各种公式估计的摄入量.
主要成果:
- 与一次24小时尿液采集相比,多次定时尿液采集,经血阿尔多素校正,在估计摄入量方面显示出明显更高的准确性.
- 在较高的摄入量 (200 mmol/day) 时,定时采集显示了跨间隔的改进,尽管可变,精度.
- 在较低的摄入量 (50 mmol/day) 时,重复定时采集的精度低于单次24小时采集,但阿尔多素校正提高了精度.
结论:
- 经过多次定时尿液采集,当对血中阿尔多素进行校正时,可在受控环境中更准确地估计每日摄入量.
- 这种方法比传统的24小时一次性尿液采集提供了潜在的改善,用于评估平衡.
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