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[用于固体瘤的收养细胞疗法]

Kenichi Sakamoto¹, Shigeki Yagyu²

¹Department of Pediatrics, Shinshu University School of Medicine.

[Rinsho ketsueki] The Japanese journal of clinical hematology

|August 4, 2024

概括

采用细胞疗法 (ACT) 对固体瘤有希望,但抗原识别和瘤微环境相互作用等挑战需要解决. 本综述探讨了当前的数据和未来的战略,以推动ACT在固体瘤中的进展.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞疗法细胞疗法

背景情况:

化学抗原受体 (CAR) T细胞疗法已经改变了耐药/复发性 (R/R) 血液恶性瘤的治疗.
六种CAR T细胞产品已被批准用于B细胞瘤和多发性髓瘤.
采用细胞疗法 (ACT) 在固体瘤中面临重大障碍.

研究的目的:

对实体瘤中ACT的临床试验数据进行审查.
阐明目前针对固体瘤的ACT开发的现状.
在实体瘤中概述ACT的轨迹和整合方法.

主要方法:

对实体瘤的ACT现有临床试验数据的审查.
对实体瘤的ACT挑战的分析.
探索克服瘤微环境的策略.

主要成果:

固体瘤的ACT因缺乏瘤特异性抗原而受到挑战.
不有效的T细胞贩运和透到瘤微环境是关键问题.
瘤环境中的免疫抑制信号诱导T细胞功能障碍.

结论:

ACT对固体瘤有潜力,但需要克服重要的生物障碍.
未来的战略必须解决抗原向,T细胞贩运和免疫抑制瘤微环境.
综合性方法对于推动ACT在固体瘤治疗方面至关重要.

关键词:

收养细胞疗法采用细胞疗法.化学抗原受体的化学抗原受体固体瘤是一个固体瘤.T细胞受体受体的 T 细胞受体.

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