基因与环境的相互作用显著改变SH2B1的肥胖风险 rs7498665载体
1Nutrition Department, Health Sciences Faculty, Ariel University, Ariel, Israel.
Journal of obesity & metabolic syndrome
|August 4, 2024
概括
这种Src同源性2B适配蛋白1 (SH2B1) rs7498665变体增加了肥胖的风险. 身体活动和压力等生活方式因素显著影响这种遗传倾向,为肥胖管理提供了潜在的干预点.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 代谢健康 代谢健康
- 人口健康 人口健康
背景情况:
- 这种Src同源性2B适应蛋白1 (SH2B1) 基因与常见的肥胖症有关.
- 在SH2B1中的特定变异可能会影响肥胖风险并与环境因素相互作用.
研究的目的:
- 调查SH2B1 rs7498665变种与常见肥胖风险之间的关联.
- 在以色列人口中探索SH2B1 rs7498665变体和生活方式/行为因素之间的相互作用.
主要方法:
- 一个队列 (n=3,070) 的分析与SH2B1 rs7498665变体数据.
- 对肥胖风险的评估 (BMI ≥25和≥30 kg/m2).
- 通过二进制后勤回归来研究与压力,饮食习惯得分 (EHS),体力活动 (PA),葡萄酒消费和禁食葡萄糖的相互作用.
主要成果:
- 在多个遗传模型中,SH2B1 rs7498665载体的超重或肥胖几率显著更高.
- 观察到rs7498665变体和生活方式因素之间存在显著的相互作用,包括PA,葡萄酒消费,压力,EHS和禁食葡萄糖.
- 身体活动和适度的葡萄酒消费降低了肥胖风险,而高压力,高EHS和高禁食葡萄糖增加了变体载体的风险.
结论:
- 这种SH2B1 rs7498665变体显著增加肥胖风险.
- 生活方式和行为因素调节由SH2B1 rs7498665.5赋予的肥胖的遗传倾向.
- 消化压力和适度的葡萄酒摄入量可以减轻肥胖风险,而高压力,EHS和禁食葡萄糖会加剧肥胖风险.
更多相关视频
14:56Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
4.5K
09:52Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
24.4K
相关概念视频
Gene-Environment Interactions
270
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
270
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Human Genetics
551
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
551
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K
Lethal Alleles
15.4K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.4K
Behavioral Genetics and Its Designs
346
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
346
