双混合物,金属混合物和2型糖尿病:从代谢物概况分析的见解
Ze Yang1, Hongbo Liu2, Jiemin Wei2
1Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, China.
双混合物,特别是双A (BPA),以及,铁和等金属与2型糖尿病 (T2DM) 风险有关. 代谢物调解这些关联,为T2DM发展提供了洞察力.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
背景情况:
- 双和金属混合物对2型糖尿病 (T2DM) 风险的联合影响在很大程度上是未知的.
- 代谢物在这些关联中的潜在调解作用需要进一步研究.
研究的目的:
- 调查双和金属混合物对T2DM风险的联合影响.
- 探索血清代谢物在环境化学物质和T2DM之间的关联中介作用.
主要方法:
- 利用超高性能液态染色体质谱法 (UPLC-MS/MS) 和感应合血质谱法 (ICP-MS) 来量化血清双和血金属.
- 采用广泛针对的代谢学和基于量子的g计算 (QG-C) 模型进行综合分析.
- 进行调解分析以确定化学T2DM关联中的代谢物作用.
主要成果:
- 双混合物,其中双A (BPA) 是主要贡献者,与增加T2DM风险有关.
- (Co),铁 (Fe) 和 (Zn) 显示对T2DM风险的影响最大,尽管金属混合物的影响是不确定的.
- 确定了154种不同的代谢物,9种介导BPA-T2DM链接和L-氨酸介导Zn-T2DM关联.
结论:
- 双A (BPA), (Co),铁 (Fe) 和 (Zn) 是导致T2DM风险的重要因素.
- 代谢物在BPA和Zn暴露和T2DM发展之间的关系中发挥着关键的调解作用.
- 这些发现有助于更好地理解将环境暴露与T2DM联系在一起的复杂机制.
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