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Updated: Jun 18, 2025

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类似Plasmodium berghei TatD的DNase通过抑制TLR9-NF-κB通路来劫持宿主的天生的免疫力

Ruiming Fan1, Qilong Li1, Ning Jiang1

  • 1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Afairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China.

International immunopharmacology
|August 4, 2024
PubMed
概括

收费类受体9 (TLR9) 对于宿主防御疟疾至关重要. 等离子体寄生虫DNase (TatD) 抑制TLR9信号传递,阻断中性粒细胞和巨细胞细胞外陷的形成,增加疟疾易感性.

关键词:
免疫清除 免疫清除网络 网络 网络 网络杆菌贝尔盖伊 (Plasmodium berghei) 是一种感染病毒.在TLR9中,这是一种类似TatD的DNase.

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