与其他呼吸道病原体共同检测SARS-CoV-2的描述性流行病学研究
Ken Arimura1, Ken Kikuchi2, Yasuto Sato3
1Tokyo Women's Medical University, Department of Respiratory Medicine, 8-1, Kawadacho, Shinjuku, Tokyo, 1628666, Japan.
Respiratory investigation
|August 4, 2024
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 与其他呼吸道病原体的联合检测在幼儿中很常见. 年龄较小是影响这些联合检测的主要因素,这需要进一步的临床研究.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 与严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 共同检测呼吸道病原体的理解仍然不充分.
- 这项研究解决了有关SARS-CoV-2和其他呼吸道感染之间的相互作用的有限知识.
研究的目的:
- 为了确定呼吸道病原体共同检测对临床变量的影响.
- 研究不同呼吸道病原体,特别是SARS-CoV-2与临床结果的相互作用.
主要方法:
- 从2020年11月到2023年3月的多重聚合酶链反应 (PCR) 测试数据的回顾性分析.
- 评估共检测率,病原体之间的相互作用 (观察到与预期),以及按年龄和性别的趋势.
- 应用多重逻辑回归模型来识别影响联合检测的因素.
主要成果:
- 在57,746名患者中,10,516人 (18.2%) 检测出至少一种病原体,881人 (1.5%) 显示共检测.
- SARS-CoV-2 与腺病毒,冠状病毒,人类甲肺病毒,偏流感病毒,呼吸道同胞性病毒和犀牛/肠道病毒表现出负面相互作用.
- 涉及SARS-CoV-2的联合检测在0-4岁年龄组中最频繁,年轻年龄被确定为最重要的影响因素.
结论:
- 与其他呼吸道病原体共同检测SARS-CoV-2很普遍,特别是在儿童群体中.
- 年龄较小是与SARS-CoV-2联合检测增加相关的关键因素.
- 需要进一步的研究,以了解与这些共同检测相关的临床影响和疾病严重程度.
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