从素中生物制造增值化学品
Arren Liu1, Dylan Ellis2, Apurv Mhatre2
1Biological Design Program, School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, USA.
Current opinion in biotechnology
|August 4, 2024
概括
生物制造业的素价值化面临着有毒,异质基质的挑战. 具有本地芳香代谢的新兴微生物为将素转化为附加值化学品提供了最有前途的解决方案.
科学领域:
- 生物技术是生物技术.
- 化学工程是化学工程的重要组成部分.
- 合成生物学 合成生物学
背景情况:
- 由于脱聚合而产生的异质和有毒化合物阻碍了宁的增值.
- 现有的生物制造方法与素衍生原料的复杂性作斗争.
研究的目的:
- 通过生物制造探索克服通过生物制造的宁价值化挑战的策略.
- 评估不同的微生物宿主系统,将芳香基质转化为增值化学品.
主要方法:
- 研究了植物细胞壁工程和用于原料制备的"素第一"预处理.
- 评估的微生物系统包括那些缺乏芳香代谢,仅代谢芳香物或共同代谢芳香物和糖的微生物系统.
主要成果:
- 植物细胞壁工程和"木质第一"方法解决了原料异质性.
- 不同的微生物系统在转化芳香基质方面表现出不同的效率.
结论:
- 具有原生芳香代谢的新兴和非模型微生物最适合用于素价值化.
- 利用这些微生物可以显著提升素衍生化学品的生物制造.
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