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微血管密度和与瘤相关的巨细胞与口面状细胞癌进展的关系

Ayesha Irfan¹, Ayesha Fahim², Varda Jalil¹

¹Department of Oral Pathology, Fatima Memorial Hospital College of Medicine and Dentistry, University of Health Sciences, Lahore, Pakistan.

Oral surgery, oral medicine, oral pathology and oral radiology

|August 4, 2024

概括

与瘤相关的巨细胞 (TAMs) 和瘤血管生成随着更高程度的口腔面状细胞癌 (OSCC) 的增加. 这项在巴基斯坦的研究发现TAMs,微血管密度 (MVD) 和OSCC等级之间存在正相关性.

科学领域:

在瘤学瘤学.
病理学病理学病理学
免疫学免疫学免疫学

背景情况:

耳鼻面状细胞癌 (OSCC) 是一个严重的健康问题.
与瘤相关的巨细胞 (TAM) 和瘤血管生成 (微血管密度,MVD) 都与癌症进展有关.
了解不同级别的OSCC中的这些因素对于预后至关重要.

研究的目的:

调查TAMs的特征及其与MVD的关联,在各种程度的口腔面状细胞癌 (OSCC) 中.
分析这些协会在巴基斯坦人口.

主要方法:

一项针对巴基斯坦234名OSCC患者的前性研究.
使用Anneroth系统对瘤进行分类.
对于CD68 (TAMs) 和CD34 (MVD) 的免疫组织化学,在高功率场中进行手动计数.

主要成果:

与差异化OSCC相比,在差异化OSCC中CD68和CD34的数量较低.
在CD68免疫反活性和瘤等级之间发现了正相关性 (r = 0.776).
在CD34免疫反活性和瘤等级 (r = 0.690) 之间,以及TAM和MVD (r = 0.680;P < .001) 之间发现了正相关性.

结论:

增加的TAMs和瘤血管生成的人口与增加的OSCC等级相关.
这些发现突出了TAMs和MVD在口腔面状细胞癌的进展中的作用.

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