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Updated: Jun 18, 2025

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DNA甲基转移酶DNMT3C的结构揭示了DNA甲基化活动调节机制

Nelli Khudaverdyan1, Jiuwei Lu1, Xinyi Chen1

  • 1Department of Biochemistry, University of California, Riverside, California, USA.

The Journal of biological chemistry
|August 4, 2024
PubMed
概括

新型DNA甲基转移酶DNMT3C对于小鼠的转子子沉默至关重要. 它的独特结构与DNMT3A/DNMT3B不同,解释了其特定的DNA甲基化活性和突变的影响.

关键词:
通过CpG甲基化.在DNA甲基转移酶中.在DNMT3A中,它是DNMT3A.在DNMT3B中,我们可以使用DNMT3B.在 DNMT3C 中使用.这是一种新的DNA甲基化.进化的共同变异.非CpG甲基化的非CpG甲基化.基质特异性 基质特异性

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