高血压患者的多药和药物使用模式:帕斯队列研究的发现
Pooria Zare1, Hossein Poustchi2, Zahra Mohammadi2
1MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Research in social & administrative pharmacy : RSAP
|August 4, 2024
概括
高血压显著增加了多药 (使用5种以上药物) 的风险. 患有高血压的个体有23.7%的多药房率,而没有的比例为4.7%,这凸显了对药物管理策略的关键需求.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 多药性,定义为同时使用五种或更多种药物,是越来越令人担忧的,特别是在患有高血压等慢性疾病的人群中.
- 在高血压患者中管理多种药物是复杂的,可能导致不良药物事件和相互作用.
研究的目的:
- 为了比较患有高血压和没有高血压的个体中多种药物的患病率.
- 确定与多药学相关的因素,并分析伊朗西南部高血压患者的药物使用模式.
主要方法:
- 一项横截面研究分析了帕斯队列研究 (PCS) 中9,270名参与者的基线数据.
- 使用Poisson多变量建模来确定多药学的相关物.
- 使用Lexicomp®和解剖治疗化学品 (ATC) 分类来评估药物相互作用和药物使用模式.
主要成果:
- 患有多种药物的患病率在患有高血压 (23.7%) 的人群中明显高于没有高血压的人群 (4.7%) (P < 0.001).
- 更高的社会经济地位和三种以上的并发症与高血压患者多药性患病率的增加有关.
- 通道阻断剂是最常见的抗高血压药物,C型药物相互作用在多种药物治疗的高血压患者中普遍存在 (76.0%).
结论:
- 高血压是多药的主要风险因素,在这个人群中非常普遍,与显著的药物相互作用一起.
- 建议包括建立国家药监系统,加强医生培训,开展公众宣传活动,并利用更安全的药物组合.
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