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Updated: Jun 20, 2026

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在急性ST升高心肌梗塞后,Ga-FAPI-04 PET/MR的潜力预测功能恶化

Lei Yi¹, Weiwei Quan¹, Min Zhang²

¹Department of cardiovascular medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International journal of cardiology

|August 4, 2024

概括

使用68Ga-FAPI-04的正子发射断层扫描 (PET) /磁共振 (MR) 可以评估心肌纤维细胞激活. 这种成像技术显示了在ST升高心肌梗塞 (STEMI) 患者中预测功能恶化的潜力.

科学领域:

心血管成像 - 心血管成像
放射性药物放射性药物放射性药物
功能评估功能评估

背景情况:

纤维细胞激活蛋白 (FAP) 是由激活的心肌纤维细胞表达的.
68Ga-标记的FAPI-04 (68Ga-FAPI-04) 定子发射断层扫描 (PET) /磁共振 (MR) 准FAP,为心肌纤维化评估提供了一种新方法.
急性ST升高心肌梗塞 (STEMI) 可以影响功能.

研究的目的:

评估68Ga-FAPI-04 PET/MR在评估心肌纤维细胞激活中的有用性.
确定68Ga-FAPI-04 PET/MR是否可以预测STEMI后功能变化.

主要方法:

33名STEMI患者在出院前接受了68Ga-FAPI-04 PET/MR和心脏MR.
功能恶化 (WRF) 被定义为12个月后估计球过率 (eGFR) 降低≥20%.
分析了基线68Ga-FAPI-04的吸收量 (UV).

主要成果:

与没有WRF (P=0.009) 的患者相比,开发WRF的患者的基线68Ga-FAPI-04紫外线显著更高 (P=0.009).
基线68Ga-FAPI-04紫外线与12个月后的EGFR负相关 (r=-0.493,P=0.004).
基线68Ga-FAPI-04紫外线是12个月后WRF的显著预测因素 (OR=1.014,P=0.029).

结论:

68Ga-FAPI-04 PET/MR有效量化了心肌纤维细胞激活的非侵入性方法.
这种成像模式具有评估和预测STEMI患者功能恶化的潜力.
68Ga-FAPI-04 PET/MR可以作为管理STEMI并发症的宝贵工具.

关键词:

剧烈的心肌梗塞急性心肌梗塞纤维细胞激活蛋白抑制剂纤维细胞激活蛋白抑制剂心肌纤维化是心肌纤维化的一种.聚乙烯 (PET) /MR (MR) 是一种恶化功能恶化功能

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