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增强siRNA癌症治疗:使用基于脂质和聚合物的载体系统的多方面的策略

Nazgol Karimi Dastgerdi¹, Nazanin Karimi Dastgerdi², Hulya Bayraktutan³

¹Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

International journal of pharmaceutics

|August 4, 2024

概括

开发有效的siRNA传递系统对于癌症治疗至关重要. 本综述研究了基于脂质和聚合物的载体,强调了提高其疗效和减少副作用的策略,以获得更好的癌症治疗结果.

科学领域:

在瘤学瘤学.
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

癌症的患病率正在上升,化学抗药性和毒性对治疗构成重大挑战.
小干扰RNA (siRNA) 疗法为癌症提供了向基因沉默,但裸体siRNA面临着降解和不良吸收等传递障碍.
有效和安全的输送工具对于基于siRNA的成功癌症疗法至关重要.

研究的目的:

审查基于脂质和聚合物的传递系统,用于siRNA治疗癌症.
探索提高siRNA传递效率和克服局限性的策略.
讨论改善siRNA癌症治疗方法的未来前景.

主要方法:

对基于脂质和聚合物的siRNA传递系统的现有文献的审查.
分析不同载体材料的优缺点.
探索组合策略和共同交付方法的探索.

主要成果:

基于脂质的系统提供了高的捕获性和成本效益;基于聚合物的系统允许化学修改.
这两种系统都保护siRNA并改善转染,但有局限性.
结合材料 (脂质,聚合物,向剂) 和联合交付策略可以提高性能和有效性.

结论:

基于脂质和聚合物的系统对siRNA癌症传递有希望,每个都有独特的优势.
涉及材料组合和共同交付的配方策略是克服当前局限性的关键.
这些先进的传递系统的进一步开发具有改善癌症治疗结果的巨大潜力.

关键词:

基于脂质的输送方式脂质/聚合物混合NP的存在基于聚合物的交付方式.聚合物/聚合物组合目标化代理人目标化代理人的 siRNA 共同交付.siRNA的传递方式

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