登记册在血液学疾病中的作用
Helen Baldomero1, Daniel Neumann2, Nada Hamad3
1Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, CH, UK.
Best practice & research. Clinical haematology
|August 4, 2024
概括
造血细胞移植 (HCT) 从高风险的手术演变为血液疾病的标准治愈疗法. 全球合作显著改善了结果,并在全球范围内增加了HCT手术的数量.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 在瘤学瘤学.
背景情况:
- 造血细胞移植 (HCT) 最初是为了治疗恶性血液疾病和骨髓衰竭而开发的.
- 存在两种主要类型:全基性HCT (使用捐赠细胞) 和自身HCT (使用患者自己的细胞).
- 这两种程序都是复杂的,并带有重大风险,特别是在早期的治疗阶段.
研究的目的:
- 提供血液细胞移植 (HCT) 的历史发展和演变的概述.
- 突出全球协作和注册表对HCT结果的影响.
- 为了强调全球越来越多的HCT活动和采用HCT作为标准护理.
主要方法:
- 血造细胞移植 (HCT) 发展的历史审查.
- 对HCT适应恶性和非恶性血液病的分析.
- 检查国际合作和登记处在推进HCT方面的作用.
主要成果:
- 血造细胞移植 (HCT) 已经从实验性手术转变为许多血液学疾病的标准护理.
- 全球协作努力和注册表已经导致HCT结果的逐步改善.
- 在1957年至2019年期间,全球已进行超过150万次HCT手术,活动不断增加.
结论:
- 造血细胞移植 (HCT) 是严重血液疾病患者的重要,拯救生命的治疗方法.
- 持续的国际合作对于进一步提高HCT的有效性和可访问性至关重要.
- 越来越多的HCT手术反映了其在临床实践中日益重要的重要性和成功.
更多相关视频
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
7.3K
06:39Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
9.8K
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Role of Hematopoietic Growth Factors
1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
Disorders of Erythrocytes
914
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
914
Overview of Hematopoiesis
3.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.9K
Hematopoiesis
5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Multipotency of Hematopoietic Stem Cells
3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
